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A CD36-dependent signaling cascade is necessary for macrophage foam cell formation

Some patients notice slight tenderness, redness, or mild swelling at the injection site, but this is temporary and resolves quickly

It has been proposed that the pathophysiology of IIM could be attributed to increased cell death, inadequate removal of cell debris, and excessive autoantigens and pro-inflammatory cytokines, which eventually result in over-stimulated immunological and inflammatory responses (152)

Jan 8, 2026 Fibromyalgia represents a central sensitization disorder where the nervous system amplifies pain signals, creating widespread discomfort from stimuli that would not normally register as painful